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Low Level Laser Research

Research on Low Level Laser Therapy

It is our goal to provide an excellent web source for users and clients to access the most current and relevant research on Low Level Laser Therapy. It seems that most research in this area is scattered all over the web and throughout specific journals and periodicals. There are thousands of clinical studies and research articles available that promote the benefits of Low Level Laser Therapy (LLLT). 

We have spent years researching laser and light technology, and through these years have compiled a list of online links to research articles and periodicals. Hopefully, this list of our favorite Low Level Laser Therapy research links will help solidify your educational journey. This list is by no means complete as there is a plethora of information on this subject available.

Keep in mind, many of the Medical Research periodicals require payment for viewing or do not allow users to copy content to websites. We have paid for viewing many periodicals; however payment does not allow us to copy the content for our users.  For this reason, we have linked to these sources, but do not have the articles in their entirety on this page. 

We encourage you to use the links below as a starting point in Low Level Laser Therapy education, and then emerge yourself in the vast amount of knowledge on the subject of Low Level Laser Therapy located outside of this website.



What is Laser Therapy and Does it Really Work?
Written By: George Gedevanishvili, M.D.


Dr. Gedevanishvili gives an overview and history of Low Level Laser Therapy. He describes how Low Level Laser Therapy is used to provide an analgesic effect in patients. He also provides a scientific explanation of how Low Level Laser Therapy works within the body.


Low Level Laser Therapy
Written By: Wikipedia


In 1967 a few years after the first working laser was invented, Endre Mester in Semmelweis University in Budapest, Hungary experimented with the effects of lasers on skin cancer. While applying lasers to the backs of shaven mice, he noticed that the shaved hair grew back more quickly on the treated group than the untreated group.

Mester started his laser research in 1965. In 1974 he founded the Laser Research Center at Semmelweis, and continued working there for the remainder of his life. He is credited with the discovery of the biological effects of low power lasers.

Mester's publications on the biostimulatory effects of the low intensity laser started in 1967.He performed early science experiments on the biological effects of laser irradiation. While applying lasers to the backs of shaven mice, Mester noticed that the shaved hair grew back more quickly on the treated group than the untreated group. Mester is believed to be only the fourth physician publishing in the area of laser medicine and surgery.

In 1971, he began treating patients with non-healing skin ulcers, while using Low Intensity Laser Irradiation.

Mester is the author of over 100 published articles in his areas of research. His two sons, Adam Mester, M.D. a radiologist, and Andrew Mester, M.D., an otolaryngologist, later assisted him in his work.

Clinical and Scientific Studies


Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials
Research By: Dr Roberta T Chow MBBS, Prof Mark I Johnson PhD, Prof Rodrigo AB Lopes-Martins PhD, Prof Jan M Bjordal PT
The Lancet, Volume 374, Issue 9705, Pages 1897 - 1908, 5 December 2009


A research group attempts to show that LLLT reduces pain immediately after treatment in acute neck pain and chronic neck pain.


Low-level laser in the treatment of patients with hypothyroidism induced by chronic autoimmune thyroiditis: a randomized, placebo-controlled clinical trial.
Research By: Höfling DB, Chavantes MC, Juliano AG, Cerri GG, Knobel M, Yoshimura EM, Chammas MC.
The Lancet, Volume 374, Issue 9705, Pages 1897 - 1908, 5 December 2009


The objective of this study was to evaluate the efficacy of low-level laser therapy (LLLT) in patients with CAT-induced hypothyroidism by testing thyroid function, thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb), and ultrasonographic echogenicity. A randomized, placebo-controlled trial with a 9-month follow-up was conducted from 2006 to 2009.


Evaluation of mitochondrial respiratory chain activity in wound healing by low-level laser therapy.
Research By:Silveira PC, Streck EL, Pinho RA.


The researchers evaluated mitochondrial respiratory chain complexes II and IV and succinate dehydrogenase activities in wounds after irradiation with low-level laser.


General Motors Study - Low Level Laser Therapy in the Treatment of Carpal Tunnel Syndrome.
Research By: Thomas E. Anderson, PhD Automotive Safety and Health Research NAO Research and Development Center
Wayne T. Good, MD Medical Department NATP Flint Assembly
Hugh H. Kerr, MD Radiology Department St. Joseph Hospital, Pontiac, MI
Byran Shumaker, MD St. John’s Hospital, Detroit, MI
Phillip J. Bendick, PhD Peripheral Vascular Laboratory
William Beaumont Hospital, Royal Oak, MI
Robert G. Nolta, MD
Flint Region Medical Director, Ret’d


This randomized double blind prospective study compares the efficacy of physical therapy
(PT) combined with low level laser therapy (LLLT) in the treatment of Carpal Tunnel Syndrome
against a program of physical therapy alone. Subjects on disability with diagnosed carpal tunnel syndrome were randomly assigned to the active or sham laser groups.


Low-level laser therapy in osteoarticular diseases in geriatric patients.
Research By:Giavelli S, Fava G, Castronuovo G, Spinoglio L, Galanti A.


Research was conducted to see if Low level laser therapy can be used to treat osteoarticular pain in geriatric patients.


Low level laser irradiation and its effect on repair processes in the skin
Research By:Matić M, Lazetić B, Poljacki M, Duran V, Ivkov-Simić M


Effects of low level laser therapy on wound healing process is one of the most fully studied aspects of this type of therapy. It affects all phases of this very complex process. This paper offers a more detailed analysis of these aspects.


Low-level laser treatment can reduce edema in second degree ankle sprains.
Research By: Stergioulas A. Faculty of Human Motion, University of Peloponnese, Attica, Greece.


The Faculty of Human Research conducted research that shows LLLT combined with RICE can reduce edema in second-degree ankle sprains.


Effect of low-level laser therapy on pain levels in patients with emporomandibular disorders: a systematic review
Research By: Mila Leite de Moraes Maia; Leonardo Rigoldi Bonjardim; Jullyana de Souza Siqueira Quintans; Maria Amália Gonzaga Ribeiro; Luiz Guilherme Martins Maia; Paulo César Rodrigues Conti


Researchers search for a potential explanation for the LLLT positive results in reducing pain levels could be a dose-specific antiinflammatory, healing and analgesic effect in TMJ as well as in the masticatory muscle painful area.


A randomised, placebo controlled trial of low level laser therapy for activated Achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E2 concentrations
Research By: J M Bjordal, R A B Lopes-Martins, V V Iversen


Low level laser therapy (LLLT) has gained increasing popularity in the management of tendinopathy and arthritis. LLLT at a dose of 5.4 J per point can reduce inflammation and pain in activated Achilles tendinitis. LLLT may therefore have potential in the management of diseases with an inflammatory component.


Low-level laser therapy (LLLT) for discogenic back pain
Research By: N Malliaropoulos, A Akritidou, I Tsifountoudis,K Tsitas


The aim of the study is to investigate the effect of low-level laser therapy (LLLT) on low back pain documented by history, clinical examination, MRI findings of the Lumbar Spine and patients' pain scores.


Advancement in the research of effect of low level laser therapy on wound healing
Research By: Mao HS, Yao M, Fang Y.


The effects of LLLT consist of promotion of tissue repair, inhibition of inflammation, and relief of pain by promoting or inhibiting the cell proliferation, increasing or decreasing the release of some bioactive substances.


The influence of low-intensity laser therapy on bone healing.
Research By: Ebrahimi T, Moslemi N, Rokn A, Heidari M, Nokhbatolfoghahaie H, Fekrazad R.


Based on the results of the reviewed articles, low intensity laser therapy can accelerate bone healing in extraction sites, bone fracture defects and distraction osteogenesis, provided proper parameters were applied.


Assessment of the Effects of Low-Level Laser Therapy on the Thyroid Vascularization of Patients with Autoimmune Hypothyroidism by Color Doppler Ultrasound
Research By: Danilo Bianchini Höfling, Maria Cristina Chavantes, Adriana G. Juliano, Giovanni G. Cerri, Meyer Knobel, Elisabeth M. Yoshimura, and Maria Cristina Chammas
ISRN Endocrinol. 2012; 2012 : 126720.
Published online 2012 December 17. doi:  10.5402/2012/126720


Objective. To evaluate the effects of low-level laser therapy (LLLT) on the thyroid vascularization of patients with hypothyroidism induced by CAT using color Doppler ultrasound parameters. In this randomized clinical trial, 43 patients who underwent levothyroxine replacement for CAT-induced hypothyroidism were randomly assigned to receive either 10 sessions of LLLT (L group, n = 23) or 10 sessions of a placebo treatment (P group, n = 20). Color Doppler ultrasounds were performed before and 30 days after interventions.


Transcranial Low-Level Laser Therapy Improves Neurological Performance in Traumatic Brain Injury in Mice: Effect of Treatment Repetition Regimen
Research By: Weijun Xuan, Fatma Vatansever, Liyi Huang, Qiuhe Wu, Yi Xuan, Tianhong Dai, Takahiro Ando, Tao Xu, Ying-Ying Huang, and Michael R. Hamblin
PLoS One. 2013; 8(1): e53454.|Published online 2013 January 7. doi:  10.1371/journal.pone.0053454


Low-level laser (light) therapy (LLLT) has been clinically applied around the world for a spectrum of disorders requiring healing, regeneration and prevention of tissue death. One area that is attracting growing interest in this scope is the use of LLLT to treat stroke and traumatic brain injury.


Effectiveness of low-level laser therapy for patients with carpal tunnel syndrome: design of a randomized single-blinded controlled trial.
Barbosa RI, da Silva Rodrigues EK, Tamanini G, Marcolino AM, Elui VM, de Jesus Guirro RR, Mazzer N, de Cássia Registro Fonseca M.
BMC Musculoskelet Disord. 2012 Dec 13;13:248. doi: 10.1186/1471-2474-13-248.


The Research paper describes the design of a randomized controlled trial, which aim to assess the effectiveness of conservative treatment added to low-level laser therapy for patients with carpal tunnel syndrome.

Low level laser versus placebo in the treatment of tennis elbow.
Vasseljen O Jr, Høeg N, Kjeldstad B, Johnsson A, Larsen S.
Scand J Rehabil Med. 1992;24(1):37-42.


The effect of low level laser (GaAs) on lateral epicondylitis was investigated in a double-blind, randomized, controlled study. Thirty patients were assigned equally to a laser (n = 15) or a placebo laser (n = 15) group.

Effects of pulse frequency of low-level laser therapy (LLLT) on bone nodule formation in rat calvarial cells
Ueda Y, Shimizu N.
J Clin Laser Med Surg. 2003 Oct;21(5):271-7.


The purpose of this study was to determine the effect of pulse frequencies of low-level laser therapy (LLLT) on bone nodule formation in rat calvarial cells in vitro.


Effect of low level laser therapy on neurovascular function of diabetic peripheral neuropathy
Written by: Abeer A. Yamany, Hayam M. Sayedb - Basic Science Department, Faculty of Physical Therapy, Cairo University, Giza, Egypt, Neuromuscular Disorders Department and Surgery, Faculty of Physical Therapy, Cairo University, Giza, Egypt


Research conducted on patients to see if Low Level Laser Therapy is an effective modality in the treatment of painful diabetic neuropathy.


A systematic review of low level laser therapy with location-specific doses for pain from chronic joint disorders
Written by: Jan M Bjordal(1), Christian Couppé(2), Roberta T Chow(3), Jan Tunér(4) and Elisabeth Anne Ljunggren(1)
1.University of Bergen, Norway 2.Lund University, Sweden 3.Private Medical Practice, Sydney 4.Private Dental Practice, Stockholm, Sweden


A researcher group investigated if low level laser therapy (LLLT) of the joint capsule can reduce pain in chronic joint disorders. A literature search identified 88 randomised controlled trials, of which 20 trials included patients with chronic joint disorders.



Low Level Laser Therapy - A Clinician's View
Written By: Bernard E. Filner - MD


A a Board-certified Anesthesiologist, having practiced anesthesiology in both an academic setting and in private practice, explains his thoughts on the benefits of Low Level Laser Therapy (LLLT).


Laser Better Than NSAIDs?
Written By: Jan Tunér, Swedish Laser Medical Society


A research group from Norway, headed by dr. Jan M. Bjordal summarises that nonsteroidal anti-inflammatory drugs (NSAIDs), including cyclo-oxygenase-2 inhibitors (coxibs), reduce short-term pain associated with knee osteoarthritis only slightly better than placebo, and long-term use of these agents should be avoided.

From the findings of a recent Norwegian Health Technology Assessment Report, laser therapy was given potential of becoming at least twice as effective as NSAIDs, if applied with optimal dose and energy.


The Light Stuff; Cold Laser Therapy Is Joining the Injury Treatment Team
Written By: Lois Lindstrom, The Washington Post


The New England Patriots won Super Bowl XXXVIII with some help from a little-known form of laser technology that could change the way athletic injuries and chronic pain are treated.


Cold Laser Therapy Used on Inflammation
Written By: Aiken Standard (Aiken, SC). McClatchy-Tribune Information Services. 2008. HighBeam Research. 23 Jan. 2013


Dr. Kim Lewis has been using cold laser therapy for two months to reduce inflammation, promote circulation and speed healing. Her approach combines cranial laser reflex technique, using a handheld pin-point laser on acupressure points, and infra-red laser technique, applying the laser directly to damaged or inflamed tissues.


Mechanisms of Low Level Light Therapy
Written By: Michael R. Hamblin, Department of Dermatology, Harvard Medical School, BAR 414 Wellman Center for Photomedicine, Massachusetts General Hospital - 40 Blossom Street, Boston MA 02114


The use of low levels of visible or near-infrared (NIR) light for reducing pain, inflammation and edema, promoting healing of wounds, deeper tissues and nerves, and preventing tissue damage has been known for almost forty years since the invention of lasers.


Laser therapy has demonstrated its impact on faster healing and reduced pain, but insurance hurdles remain
Written By: Kerri Reeves
Published By: Advance: For Physical Therapy and Rehab Medicine


Low-level laser therapy (LLLT) is a pain-free, non-invasive, affordable tool used by physical therapists throughout the healing process that is becoming more prevalent in PT practices nationwide. Unlike surgical lasers, which produce heat and cut tissue, low-level cold lasers are absorbed into the skin to increase cellular activity in tissues, which can bring healing to injured areas.


It is time to test low level laser therapy in Great Britain
T Moshkovska and J Mayberry


Low level laser therapy (LLLT) has been used in Eastern Europe and Asia for the treatment of a wide range of conditions for many years. Its continued acceptance in these populations reflects the efficacy with which it is regarded both by clinicians and their patients. Although there have been a substantial number of reports on its clinical benefit and some practitioners have used the technique in North America and Australasia it has yet to be subjected to detailed assessment through randomised clinical trials. The purpose of this review is to stimulate interest in the technique and to encourage rigorous research into its potential value.


Please note that low level laser therapy does not work for every person. This system is not intended to diagnose, treat, cure, mitigate or prevent disease. We recommend consulting with your physician or health care professional if you have a disease, medical condition, or concerned about a health related issue.

This system and the statements on this site have not been evaluated by the Food & Drug Administration and make no claims to cure any illness, disease, or ailment. This website and Lectro Life Technologies, LLC do not make claims, diagnose, mitigate, treat, nor cure any physiological, emotional, neurological, or spiritual conditions. None of the information provided on this site is intended to act as a substitute for medical counseling.